|
Status |
Public on Jan 25, 2007 |
Title |
Foxp3 ablation in peripheral mature regulatory T cells |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
|
Summary |
Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3. Keywords: genetic modification
|
|
|
Overall design |
Compare Cre recombinase treated peripheral regulatory T cells possessing a Cre sensitive Foxp3 locus to Cre treated regulatory T cells with a wild type Foxp3 locus. Cre exposure is observed via the Cre sensitive expression of the yellow flourescent protein molecule.
|
|
|
Contributor(s) |
Williams LM, Rudensky AY |
Citation(s) |
17220892 |
|
Submission date |
Jan 08, 2007 |
Last update date |
Feb 11, 2019 |
Contact name |
Alexander Rudensky |
Organization name |
University of Washington
|
Department |
Immunology
|
Street address |
1959 Pacific St
|
City |
Seattle |
State/province |
WA |
ZIP/Postal code |
98195 |
Country |
USA |
|
|
Platforms (1) |
GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
Samples (4)
|
|
Relations |
BioProject |
PRJNA99057 |