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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 05, 2016 |
| Title |
NPM‐ALK permits the survival of thymic T cells with aberrant T cell receptor rearrangements enabling thymic escape and tumor development |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
We present evidence to support a new model of Anaplastic Large Cell Lymphoma (ALCL) pathogenesis in which the malignancy is initiated in early thymocytes, prior to TCR rearrangement which is bypassed in NPM‐ALK transgenic mice following Notch1 expression. In support, we show that T cell receptor (TCR) rearrangements are aberrant in some human ALCL, yielding events that would not normally be permissive for survival during T cell development. However, a TCR is required for thymic egress and subsequent development of peripheral tumors in mice yet this TCR must be down‐regulated for T‐cell lymphomagenesis. Children affected by ALCL may thus harbor lymphoma-initiating cells in the thymocyte population that seeds relapse after chemotherapy.
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| Overall design |
comparative genomic hybridization data from 43 human Anaplastic Large Cell Lymphoma (ALCL) samples and control samples
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| Contributor(s) |
Malcolm T, Villarese P, Fairbairn C, Lamant L, Trinquand A, Hook E, Burke A, Brugières L, Hughes K, Payet D, Merke O, Schiefer A, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner S |
| Citation(s) |
26753883 |
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| Submission date |
Mar 20, 2015 |
| Last update date |
Jul 03, 2019 |
| Contact name |
Mohamed BELHOCINE |
| E-mail(s) |
mrbelhocine.mohamed@gmail.com
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| Phone |
+33650954508
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| Organization name |
INSERM
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| Lab |
Technological Advances for Genomics and Clinics (TAGC)
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| Street address |
163, Avenue de Luminy
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| City |
Marseille |
| ZIP/Postal code |
13288 |
| Country |
France |
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| Platforms (1) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
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| Samples (43)
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| Relations |
| BioProject |
PRJNA279168 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE67131_RAW.tar |
793.2 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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