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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 05, 2015 |
| Title |
Furin deficiency effect on T cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of T-cells lacking the proprotein convertase furin. Proprotein convertases promote the proteolytic maturation of proproteins. Furin is induced in activated T-cells. Results provide insight into the function of furin in T-cells.
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| Overall design |
CD4+CD62L+CD44- naive, CD4+CD62L-CD44+ memory and CD4+CD25+FoxP3+ regulatory T cells were isolated from Fur flox/flox and CD4 cre Fur flox/flox mice. Naive T cells were activated via TCR. Total RNA was extracted from all cells and hybridized to Affymetrix microarrays.
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| Contributor(s) |
Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O´Shea JJ, Ortutay Z, Oksanen A, Aittomäki S, Ortutay C |
| Citation(s) |
25926688 |
| Submission date |
Apr 14, 2015 |
| Last update date |
Oct 19, 2020 |
| Contact name |
Ilkka Junttila |
| E-mail(s) |
ilkka.junttila@tuni.fi
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| Organization name |
University of Tampere
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| Department |
Institute of Medical and Life Science
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| Lab |
Cytokine biology
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| Street address |
Arvo Ylpön katu 34
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| City |
Tampere |
| State/province |
Tampere |
| ZIP/Postal code |
33520 |
| Country |
Finland |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| GSM1657547 |
Furin_cKO_CD4+CD62L-CD44+_memoryTcells |
| GSM1657548 |
WT_CD4+CD25+FoxP3+_regulatoryTcells |
| GSM1657549 |
Furin_cKO_CD4+CD25+FoxP3+_regulatoryTcells |
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| Relations |
| BioProject |
PRJNA281111 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE67884_RAW.tar |
35.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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