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| Status |
Public on Apr 28, 2015 |
| Title |
Comparative Analysis of Gene Expression Profiles in Infective and Developing Larvae of Brugia malayi and Brugia pahangi |
| Platform organisms |
Brugia malayi; Onchocerca volvulus; Wuchereria bancrofti; Wolbachia endosymbiont strain TRS of Brugia malayi |
| Sample organisms |
Brugia malayi; Brugia pahangi |
| Experiment type |
Expression profiling by array
|
| Summary |
Comparative analysis of gene expression profiles provided novel insights into the genes that are transcriptionally active in infective and developing larvae of two closely related species. Species differences may indicate different metabolic adaptations that could affect host specificity, tissue tropism, and pathogenicity
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| Overall design |
Two biological replicates of infective (L3) or developing larval RNA used for hybridization, in duplicate, to examine the gene expression changes in Brugia larvae
Brugia malayi vector derived third stage larvae (Bm VL3); Brugia pahangi vector derived third stage larvae (Bp VL3); Brugia pahangi L3 cultured in vitro (Bp cL3); Brugia pahangi L3 derived from peritoneal cavity of infected gerbils (Bp ipL3); Brugia pahangi migrating L3 (Bp mL3) from infected gerbils
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| Contributor(s) |
Rao R, Crosby SD, Weil GJ, Klei TR, Heinz M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 27, 2015 |
| Last update date |
Apr 29, 2015 |
| Contact name |
Michael Heinz |
| Organization name |
Washington University School of Medicine
|
| Department |
Genetics
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| Lab |
GTAC
|
| Street address |
4320 Forest Park Blvd.
|
| City |
St. Louis |
| State/province |
MO |
| ZIP/Postal code |
63108 |
| Country |
USA |
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| Platforms (1) |
| GPL10232 |
Washington University School of Medicine Microarray Core Brugia malayi microarray V.2 |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA282400 |
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