NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE68339 Query DataSets for GSE68339
Status Public on Sep 14, 2015
Title Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Methylation profiling by array
Summary We performed integrative methylation, gene dosage and expression profiling to explore the interplay between promoter methylation and loss in gene silencing at 3p11-p14 in cervical cancer.
Totally 26 hypermethylated genes were identified by comparing the methylation level of individual CpG sites with corresponding data of normal cervical tissue. Candidate methylation regulated genes in tumors were proposed from the correlation between methylation and gene expression. Integrated analysis of methylation, gene dosage and expression revealed three significant regulation patterns encompassing 8 hypermethylated genes; a methylation driven pattern, a gene dosage driven pattern, and a combined methylation and gene dosage driven pattern. For the LRIG1 gene, patients with both hypermethylation and loss had a worse outcome compared to those harboring only hypermethylation or none of the events. C3orf14 emerged as a novel methylation regulated suppressor gene, for which knockdown was found to promote invasive growth in human papilloma virus (HPV)-transformed keratinocytes.
 
Overall design Methylation levels from Illumina 450K methylation arrays were correlated with Illumina gene expression data in cohort 1 and validated in cohort 2.
 
Contributor(s) Lando M, Fjeldbo CS, Wilting SS, Forsberg MF, Kristensen GB, Steenbergen RD, Lyng H
Citation(s) 26291246
Submission date Apr 28, 2015
Last update date Mar 22, 2019
Contact name Heidi Lyng
E-mail(s) heidi.lyng@rr-research.no
Phone 4722781478
Organization name Oslo University Hospital
Department Department of Radiation Biology
Street address Montebello
City Oslo
ZIP/Postal code 0310
Country Norway
 
Platforms (2)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (391)
GSM1668684 Tumor biopsy [P-003]
GSM1668685 Tumor biopsy [P-008]
GSM1668686 Tumor biopsy [P-009]
Relations
Affiliated with GSM678702
Affiliated with GSM678703
Affiliated with GSM678704
Affiliated with GSM678705
Affiliated with GSM678706
Affiliated with GSM678707
Affiliated with GSM678709
Affiliated with GSM678710
Affiliated with GSM678712
Affiliated with GSM678713
Affiliated with GSM678715
Affiliated with GSM678717
Affiliated with GSM678718
Affiliated with GSM678719
Affiliated with GSM678720
Affiliated with GSM678721
Affiliated with GSM678722
Affiliated with GSM678723
Affiliated with GSM678724
Affiliated with GSM678725
Affiliated with GSM678726
Affiliated with GSM678727
Affiliated with GSM678728
Affiliated with GSM678730
Affiliated with GSM678732
Affiliated with GSM678733
Affiliated with GSM678734
Affiliated with GSM678735
Affiliated with GSM678736
Affiliated with GSM678737
Affiliated with GSM678738
Affiliated with GSM678739
Affiliated with GSM678740
Affiliated with GSM678741
Affiliated with GSM678742
Affiliated with GSM678743
Affiliated with GSM678744
Affiliated with GSM678745
Affiliated with GSM678746
Affiliated with GSM678747
Affiliated with GSM678748
Affiliated with GSM678749
Affiliated with GSM678750
Affiliated with GSM678751
Affiliated with GSM678754
Affiliated with GSM678755
Affiliated with GSM678756
Affiliated with GSM678757
Affiliated with GSM678758
Affiliated with GSM678759
Affiliated with GSM678761
Affiliated with GSM678762
Affiliated with GSM678763
Affiliated with GSM678764
Affiliated with GSM678765
Affiliated with GSM678766
Affiliated with GSM678767
Affiliated with GSM678768
Affiliated with GSM678769
Affiliated with GSM678770
Affiliated with GSM678771
Affiliated with GSM678772
Affiliated with GSM678773
Affiliated with GSM678774
Affiliated with GSM678775
Affiliated with GSM678776
Affiliated with GSM678777
Affiliated with GSM678778
Affiliated with GSM678779
Affiliated with GSM678780
Affiliated with GSM678781
Affiliated with GSM678782
Affiliated with GSM678783
Affiliated with GSM738916
Affiliated with GSM738917
Affiliated with GSM738918
Affiliated with GSM738919
Affiliated with GSM738920
Affiliated with GSM738921
Affiliated with GSM738922
Affiliated with GSM738923
Affiliated with GSM738924
Affiliated with GSM738925
Affiliated with GSM738926
Affiliated with GSM738927
Affiliated with GSM738928
Affiliated with GSM738929
Affiliated with GSM738930
Affiliated with GSM738931
Affiliated with GSM738932
Affiliated with GSM738933
Affiliated with GSM738934
Affiliated with GSM738935
Affiliated with GSM738936
Affiliated with GSM738937
Affiliated with GSM738938
Affiliated with GSM738939
Affiliated with GSM738940
Affiliated with GSM738941
Affiliated with GSM738942
Affiliated with GSM738943
Affiliated with GSM738944
Affiliated with GSM738945
Affiliated with GSM738946
Affiliated with GSM738947
Affiliated with GSM738948
Affiliated with GSM738949
Affiliated with GSM738950
Affiliated with GSM738951
Affiliated with GSM738952
Affiliated with GSM738953
Affiliated with GSM738954
Affiliated with GSM738955
Affiliated with GSM738956
Affiliated with GSM738957
Affiliated with GSM738958
Affiliated with GSM738959
Affiliated with GSM738960
Affiliated with GSM738961
Affiliated with GSM738962
Affiliated with GSM738963
Affiliated with GSM738964
Affiliated with GSM738965
Affiliated with GSM738966
Affiliated with GSM738967
Affiliated with GSM738968
Affiliated with GSM738969
Affiliated with GSM738970
Affiliated with GSM738971
Affiliated with GSM738972
Affiliated with GSM738973
Affiliated with GSM738974
Affiliated with GSM738975
Affiliated with GSM738976
Affiliated with GSM738977
Affiliated with GSM738978
Affiliated with GSM738979
Affiliated with GSM738980
Affiliated with GSM738981
Affiliated with GSM738982
Affiliated with GSM738983
Affiliated with GSM738984
Affiliated with GSM738985
Affiliated with GSM738986
Affiliated with GSM738987
Affiliated with GSM738988
Affiliated with GSM738989
BioProject PRJNA282483

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE68339_Matrix_non-normalized_121Patients.txt.gz 32.7 Mb (ftp)(http) TXT
GSE68339_Matrix_normalized_121Patients.txt.gz 31.7 Mb (ftp)(http) TXT
GSE68339_Metylering.cohort1.149pas.norm_TilGEO.txt.gz 574.3 Mb (ftp)(http) TXT
GSE68339_Metylering.cohort1.unorm.149pas_TilGEO.txt.gz 345.8 Mb (ftp)(http) TXT
GSE68339_Metylering.cohort2.norm.121pas_TilGEO_sortert.txt.gz 467.2 Mb (ftp)(http) TXT
GSE68339_Metylering.cohort2.unorm.121pas_TilGEO_sortert.txt.gz 271.7 Mb (ftp)(http) TXT
GSE68339_RAW.tar 209.3 Mb (http)(custom) TAR
GSE68339_cohort_information.xls.gz 18.3 Kb (ftp)(http) XLS
GSE68339_re-used_matrix.txt.gz 36.3 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap