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Series GSE68604 Query DataSets for GSE68604
Status Public on May 05, 2018
Title Trancriptional profiling of rat bladder after daily administration of Pioglitazone and Rosiglitazone in vivo (miRNA)
Organism Rattus norvegicus
Experiment type Non-coding RNA profiling by array
Summary The purpose of the study was to investigate the nongenotoxic carcinogenic effect of Pioglitazone. Pioglitazone is a PPARgamma agonist and is known to cause bladder tumours in male rats and an increase in the incidence of bladder cancer in humans has been observed in patients treated with Pioglitazone. Pioglitazone is not considered genotoxic or carcinogenic in mice and tumours are only observed in male rats suggesting a nongenotoxic mechanism of tumorigenesis. A suggested hypothesis is urinary calculi formation and subsequent irritation, hyperplasia and metaplasia. Rosiglitazone was used as reference compound as this PPARgamma agonist does not cause changes in the bladder but cause lipoma/liposarcoma in rats.
 
Overall design Sprague-Dawley rats were dosed for 3 time periods: 3, 28 or 90 days. The animals (10/sex/group) were dosed orally with vehicle (0.5 % methylcellulose), Pioglitazone (13 and 63 mg/kg/day) or Rosiglitazone (10 mg/kg/day). Bladder urothelium was isolated from 5 animals/sex/group and further processed for transcriptional profiling.
 
Contributor(s) Römer M, Ostenfeldt N, Toft DB, Wegener KM, Zollinger T, Terranova R, Moggs J, Quinney J, Elcombe C
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Submission date May 06, 2015
Last update date May 06, 2018
Contact name Jonathan Moggs
E-mail(s) jonathan.moggs@novartis.com
Organization name Novartis
Street address Fabrikstrasse 2
City Basel
ZIP/Postal code 4056
Country Switzerland
 
Platforms (1)
GPL14860 Agilent-031189 Unrestricted_Rat_miRNA_v16.0_Microarray (miRNA ID version)
Samples (119)
GSM1676734 Control_F_28d_1 [miRNA]
GSM1676735 Control_F_28d_2 [miRNA]
GSM1676736 Control_F_28d_3 [miRNA]
This SubSeries is part of SuperSeries:
GSE68387 IMI MARCAR Project: towards novel biomarkers for cancer risk assessment
Relations
BioProject PRJNA283201

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE68604_RAW.tar 91.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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