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| Status |
Public on Feb 10, 2017 |
| Title |
Transcriptional Profiling of the Immune Response to Ebola Infection |
| Platform organism |
Homo sapiens |
| Sample organisms |
Macaca fascicularis; Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Ebola virus is the causative agent of a severe syndrome in humans with a fatality rate that can approach 90%. During infection, the host immune response is thought to become dysregulated, but the mechanisms through which this happens are not entire understood. In this study, we use microarrays to determine the host response to Ebola infection in the PBMCs of cynomolgus macaques.
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| Overall design |
RNA was isolated from a total of 36 PBMC samples from 14 cynomologus macaques infected with Ebola Virus. Samples were obtained at sequential timepoints post-infection, and included a pre-infection specimen from each animal. These samples were then processed and hybridized onto the Agilent 2-color arrays.
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| Contributor(s) |
Yen JY, Caballero IS, Honko AN, Hensley L, Connor JH |
| Citation(s) |
27595844 |
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| Submission date |
May 12, 2015 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Ignacio S. Caballero |
| E-mail(s) |
nacho@bu.edu
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| Organization name |
Boston University School of Medicine
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| Department |
NEIDL/Microbiology
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| Street address |
620 Albany St., NEIDL 401V
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02118 |
| Country |
USA |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (36)
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| GSM1682188 |
EBOV PBMC, Mky 061913 Day 0 |
| GSM1682189 |
EBOV PBMC, Mky 062098 Day 0_1 |
| GSM1682190 |
EBOV PBMC, Mky 062059 Day 0_1 |
| GSM1682191 |
EBOV PBMC, Mky R060052 Day 0_1 |
| GSM1682192 |
EBOV PBMC, Mky 062009x Day 0_1 |
| GSM1682193 |
EBOV PBMC, Mky 061944 Day 0 |
| GSM1682194 |
EBOV PBMC, Mky R050148 Day 0 |
| GSM1682195 |
EBOV PBMC, Mky 062063 Day 0_1 |
| GSM1682196 |
EBOV PBMC, Mky 051822x Day 0 |
| GSM1682197 |
EBOV PBMC, Mky 051783 Day 0 |
| GSM1682198 |
EBOV PBMC, Mky 062098 Day 0_2 |
| GSM1682199 |
EBOV PBMC, Mky 062059 Day 0_2 |
| GSM1682200 |
EBOV PBMC, Mky R060052 Day 0_2 |
| GSM1682201 |
EBOV PBMC, Mky 062009x Day 0_2 |
| GSM1682202 |
EBOV PBMC, Mky 062063 Day 0_2 |
| GSM1682203 |
EBOV PBMC, Mky R050096 Day 1 |
| GSM1682204 |
EBOV PBMC, Mky 061973x Day 1 |
| GSM1682205 |
EBOV PBMC, Mky 051892 Day 3 |
| GSM1682206 |
EBOV PBMC, Mky 061913 Day 3 |
| GSM1682207 |
EBOV PBMC, Mky 062098 Day 4_1 |
| GSM1682208 |
EBOV PBMC, Mky 062059 Day 4_1 |
| GSM1682209 |
EBOV PBMC, Mky 062098 Day 4_2 |
| GSM1682210 |
EBOV PBMC, Mky 062059 Day 4_2 |
| GSM1682211 |
EBOV PBMC, Mky R060052 Day 5_1 |
| GSM1682212 |
EBOV PBMC, Mky 062009x Day 5_1 |
| GSM1682213 |
EBOV PBMC, Mky R060052 Day 5_2 |
| GSM1682214 |
EBOV PBMC, Mky 062009x Day 5_2 |
| GSM1682215 |
EBOV PBMC, Mky 061944 Day 6 |
| GSM1682216 |
EBOV PBMC, Mky 061993 Day 6 |
| GSM1682217 |
EBOV PBMC, Mky R050148 Day 7 |
| GSM1682218 |
EBOV PBMC, Mky 062063 Day 7 |
| GSM1682219 |
EBOV PBMC, Mky 051822x Day 8 |
| GSM1682220 |
EBOV PBMC, Mky 051783 Day 8 |
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| Relations |
| BioProject |
PRJNA283829 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE68809_Normalized_data_with_probe_name.txt.gz |
8.4 Mb |
(ftp)(http) |
TXT |
| GSE68809_RAW.tar |
462.6 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
| Processed data are available on Series record |
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