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| Status |
Public on Jul 01, 2016 |
| Title |
Replication timing of control and siRNA PR-set7 cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing and time activation of replication origins in mammalian cells.
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| Overall design |
Two experimental condition : shRNA LUC cells (control) versus siRNA Prset-7 cells
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| Contributor(s) |
Brustel J, Dulev S, Kirstein N, Izard F, Grimaud C, Cayrou C, Schotta G, Mechali M, Baldacci G, Sardet C, Batada NN, Cadoret J, Schepers A, Julien E |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 20, 2015 |
| Last update date |
Jul 02, 2016 |
| Contact name |
Jean-Charles Cadoret |
| E-mail(s) |
jean-charles.cadoret@ijm.fr
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| Organization name |
CNRS/ Université de Paris
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| Street address |
15 rue hélène Brion
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| City |
Paris |
| ZIP/Postal code |
75013 |
| Country |
France |
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| Platforms (1) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE69085 |
Degree of H4-K20me defines distinct subsets of replication origins in active and silent chromatin domains of mammalian cells |
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| Relations |
| BioProject |
PRJNA284499 |
