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| Status |
Public on Jul 01, 2016 |
| Title |
Replication timing of control and suv4-20h (KO and inducible mutant) cells |
| Platform organism |
Homo sapiens |
| Sample organism |
Mus musculus |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the trimethylation, is a critical determinant of licensing and time activation of replication origins in mammalian cells.
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| |
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| Overall design |
WT cells versus suv4-20h KO cells, and non-induced cells versus induced cells
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| |
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| Contributor(s) |
Brustel J, Dulev S, Kirstein N, Izard F, Grimaud C, Cayrou C, Schotta G, Mechali M, Baldacci G, Sardet C, Batada NN, Cadoret J, Schepers A, Julien E |
| Citation(s) |
28778956 |
| |
| Submission date |
May 20, 2015 |
| Last update date |
Jun 05, 2019 |
| Contact name |
Jean-Charles Cadoret |
| E-mail(s) |
jean-charles.cadoret@ijm.fr
|
| Organization name |
CNRS/ Université de Paris
|
| Street address |
15 rue hélène Brion
|
| City |
Paris |
| ZIP/Postal code |
75013 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL10123 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version) |
|
| Samples (4)
|
| GSM1692640 |
induced suv4-20h mutant replication timing |
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| This SubSeries is part of SuperSeries: |
| GSE69085 |
Degree of H4-K20me defines distinct subsets of replication origins in active and silent chromatin domains of mammalian cells |
|
| Relations |
| BioProject |
PRJNA284498 |
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