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Series GSE69406 Query DataSets for GSE69406
Status Public on Jun 03, 2015
Title Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Natural killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56+/cytoCD3+ lymphocytes and constitutes a heterogeneous group of aggressive lymphomas prevalent in Asian and South American populations. Molecular pathogenesis of NKTCL remains largely elusive. Here we identified somatic mutations in RNA helicase gene DDX3X. Gene expression profiling revealed an association of DDX3X mutations with activation of NF-kB and MAPK pathways. Together, our work suggests the heterogeneity of gene mutational spectrum in NKTCL.
 
Overall design We identified somatic mutations in RNA helicase gene DDX3X. To determine whether these mutations have influence on gene expresson, whole genome expression microarray was employed on 5 Natural killer/T-cell lymphoma patients with mutations in DDX3X and 5 patients without these mutations. The expression profile of NK cell line KAI3 was also detected on 2 samples with different mutations (E348K andA404P) and 1 wildtype sample.
 
Contributor(s) Chen Z, Chen S
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Submission date Jun 01, 2015
Last update date Jun 30, 2017
Contact name Mingjie Wang
E-mail(s) huzai920621@126.com
Organization name Ruijin Hospital,Shanghai Jiaotong University,School of Medicine
Street address 197 Ruijin Er Road
City shanghai
ZIP/Postal code 200025
Country China
 
Platforms (1)
GPL10332 Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Feature Number version)
Samples (13)
GSM1700790 tumor_tissue_DDX3X_mutation_1
GSM1700791 tumor_tissue_DDX3X_mutation_2
GSM1700792 tumor_tissue_DDX3X_mutation_3
Relations
BioProject PRJNA285526

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69406_RAW.tar 35.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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