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Series GSE69730 Query DataSets for GSE69730
Status Public on Nov 04, 2016
Title TRAF6, a master activator of p53 transactivation, suppresses mitochondrial p53 and apoptosis
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary TRAF6 -/- thymi display defects in IR-induced p53 target gene expression and attenuate further enhancement of apoptosis upon IR treatment.
TRAF6-mediated K63-linked ubiquitination of p53 at K24
 
Overall design 2.5 week WT and TRAF6 null mice were IR (15Gy) treated for 10h, thymi were then isolated and RNA was extracted by standard Trizol methods. H1299 cells were transfected with p53 wt and K24R mutant, RNA was extracted by standard Trizol methods.
 
Contributor(s) Lin H, Zhang X
Citation(s) 27818144
Submission date Jun 10, 2015
Last update date Nov 10, 2016
Contact name Xian Zhang
E-mail(s) zhangxian1987@gmail.com
Organization name MSKCC
Street address 580 main st apt 138
City New York
ZIP/Postal code 10044
Country USA
 
Platforms (2)
GPL10904 Illumina HumanHT-12 V4.0 expression beadchip (gene symbol)
GPL18752 Illumina MouseWG-6 v2.0 expression beadchip [gene symbol version]
Samples (8)
GSM1707930 WT NO IR
GSM1707931 WT IR1
GSM1707932 WT IR2
Relations
BioProject PRJNA286309

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69730_RAW.tar 12.7 Mb (http)(custom) TAR (of IDAT)
GSE69730_non_normalized_human.txt.gz 1.4 Mb (ftp)(http) TXT
GSE69730_non_normalized_mouse.txt.gz 1.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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