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Series GSE69827 Query DataSets for GSE69827
Status Public on Jul 11, 2015
Title Differential expression profiles of type I JAK inhibitor persistent vs. naïve MPN cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The type I JAK inhibitor ruxolitinib is approved for therapy of MPN patients but evokes resistance with longer exposure. Several novel type I JAK inhibitors were studied and we show that they uniformly induce resistance via a shared mechanism of JAK family heterodimer formation.Here we studied the expression profiles of SET2 cell lines persistent to several different type I JAK inhibitors in comparison to naive SET2 cells or in comparison to SET2 cells with acute exposure to ruxolitinib.
 
Overall design Analysis of RNA isolated from several type I JAK inhibitor SET2 cell lines in comparison to naïve SET2 cells
 
Contributor(s) Meyer S, Rapaport F, Levine R
Citation(s) 26175413
Submission date Jun 12, 2015
Last update date May 15, 2019
Contact name Jeffrey Zhao
Organization name Memorial Sloan Kettering Cancer Center
Department Genomics Core
Street address 1275 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
 
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (24)
GSM1817323 SET2 cells persistent to BMS911543_replicate 1
GSM1817324 SET2 cells persistent to BMS911543_replicate 2
GSM1817325 SET2 cells persistent to BMS911543_replicate 3
Relations
BioProject PRJNA289489
SRA SRP060655

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Supplementary file Size Download File type/resource
GSE69827_normalizedCounts.txt.gz 2.6 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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