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| Status |
Public on Aug 01, 2015 |
| Title |
The role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndrome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Schnitzler’s syndrome (SchS) is a disabling autoinflammatory disorder, characterized by chronic urticaria a chronic urticarial rash, an M-protein, arthralgia, and other signs of systemic inflammation. Anti-interleukin-1 (IL-1) beta antibodies are highly effective, but the pathophysiology is still largely unknown. Here we studied the effect of in-vivo IL-1 inhibition on serum markers of inflammation and cellular immune responses.
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| Overall design |
Transcriptome analysis of RNA from PBMCs from three patients with Schnitzler’s syndrome and three matched controls. Patient samples were drawn during symptomatic disease, anakinra and canakinumab treatment.
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| Contributor(s) |
de Koning HD, Schalkwijk J, Stoffels M, Jongekrijg J, Jacobs JF, Verwiel ET, Koenen HJ, Preijers F, Holzinger D, Joosten I, van der Meer JW, Simon A |
| Citation(s) |
26198339 |
| |
| Submission date |
Jun 19, 2015 |
| Last update date |
Jan 28, 2016 |
| Contact name |
Heleen de Koning |
| E-mail(s) |
heleen.dekoning@radboudumc.nl
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| Organization name |
Radboudumc
|
| Street address |
Geert Grooteplein-Zuid 10
|
| City |
Nijmegen |
| State/province |
Gelderland |
| ZIP/Postal code |
6525GA |
| Country |
Netherlands |
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| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA287499 |
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