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Series GSE70306 Query DataSets for GSE70306
Status Public on Jun 27, 2015
Title Comparison of mRNA expression pattern between wild-type regulatory T (Treg) cells and Nr4a-deficient Treg cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many aspects of immune system physiology and pathophysiology. Treg cells are characterized by a distinct pattern of gene expression, including upregulation of immune-suppressive genes and silencing of inflammatory cytokine genes. However, the molecular mechanisms that establish and/or maintain such gene regulation in Treg cells remain largely unknown. We recently reported that Nr4a family nuclear orphan receptors are essential for the development of Treg cells. The fact that Treg cells maintain high levels of expression of all Nr4a family components suggests that they may also play critical roles beyond Treg cell development. Thus, we compared mRNA expression pattern between wild-type Treg cells and Nr4a-deficietn Treg cells. As a result, we found that expression of 'Treg-signature genes' were globally down regulated in Nr4a-deficient Treg cells.
Overall design mRNA from wild-type and Nr4a-deficient Treg cells were analyzed.
Contributor(s) Sekiya T, Yoshimura A
Citation(s) 26304965
Submission date Jun 26, 2015
Last update date Nov 01, 2017
Contact name Takashi Sekiya
Organization name National Center for Global Health and Medicine
Street address 1-7-1 Kohnodai
City Ichikawa
State/province Chiba
ZIP/Postal code 272-0827
Country Japan
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (2)
GSM1723513 Nr4a-deficient
GSM1723514 Wild-type
BioProject PRJNA288291

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE70306_RAW.tar 18.0 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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