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| Status |
Public on Sep 16, 2015 |
| Title |
Fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation [Rn] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Determination of the mechanism by which fibrinogen, a central blood coagulation protein drives immunological responses targeted to the CNS. Results identify the factors involved in the regulation and provide mechanistic basis.
We subjected fibrin-stimulated microglia to microarray to determine the genes involved in innate and adaptive immune responses by fibrinogen deposited in the CNS after blood-brain barrier disruption.
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| Overall design |
Rat microglia were stimulated with fibrin for 6 hr and subjected for RNA extraction and hybridization on Affymatrix microarrays. Two unstimulated and two fibrin-stimulated samples were generated.
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| Contributor(s) |
Akassoglou K, Ryu J |
| Citation(s) |
26353940 |
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| Submission date |
Jul 20, 2015 |
| Last update date |
Dec 16, 2015 |
| Contact name |
Katerina Akassoglou |
| E-mail(s) |
katerina.akassoglou@gladstone.ucsf.edu
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| Phone |
4157342512
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| Organization name |
Gladstone Institutes
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| Street address |
1650 Owens St
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| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
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| Platforms (1) |
| GPL6247 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE71084 |
Fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation |
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| Relations |
| BioProject |
PRJNA290323 |
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