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Series GSE72138 Query DataSets for GSE72138
Status Public on Jun 12, 2017
Title Globally construct ceRNA regulation network based on comparison with SHEE and SHEEC cell lines
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Long non-coding RNAs (lncRNAs), new star ncRNA class of mRNA-like transcripts, play complicate and critical roles in regulating various key biological processes including chromatin modification, transcription and post-transcriptional processing. Remarkably, some lncRNAs serve as a miRNA “sponge” to inhibit mediation of the differentiation of miRNA target in post-transcriptional regulation. Here, we firstly constructed the putative ceRNA network by integrating lncRNAs, miRNAs and mRNAs expression in compared with SHEE and SHEEC cell lines based on the high-though RNA sequencing data and microarray data. Though the biology function analysis, the result showed that ceRNA network mainly participate in PI3K-Akt pathway and may play a modulating role in regulation of essential signal molecules including SYK, FGF11, IL7R, MET, LAMB3, PRS6KB1, ITGB6, ITGB4, ITGA2, ITGA6, EPHA2, SOS2, VEGFA, GRB2, KRAS, CCDN1 and TP53 in primary ESCC. These results could provide us more essential clues for the development of novel therapeutic strategies and efficient drugs target in primary ESCC.
 
Overall design The SHEEC and SHEE cell lines were pooled with 5 cell lines respectively.
 
Contributor(s) Sun J
Citation(s) 28536623
Submission date Aug 18, 2015
Last update date Jun 14, 2017
Contact name Jiachun Sun
Organization name Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University of Science and Technology
Street address 24 Jinghua road, Jianxi district
City Luoyang
State/province Henan
ZIP/Postal code 471003
Country China
 
Platforms (1)
GPL20814 Human miRNA Array miRbase release 19
Samples (2)
GSM1855902 SHEEC cell lines
GSM1855903 SHEE cell lines
Relations
BioProject PRJNA293166

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Supplementary file Size Download File type/resource
GSE72138_RAW.tar 1.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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