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Series GSE72328 Query DataSets for GSE72328
Status Public on May 12, 2016
Title Comparison of gene expression in M. tuberculosis TrxB2-TetON-tetO-WT mutant treated or not with atc
Organism Mycobacterium tuberculosis H37Rv
Experiment type Expression profiling by array
Summary M. tuberculosis thioredoxin reductase (TrxB2) is essential for Mtb physiology and pathogenesis. To gain insight into its biological functions, we generated the TrxB2-TetON-tetO mutants, in which TrxB2 is partially depleted in the absence of atc without impairing bacterial viability.
 
Overall design We grew TrxB2-TetON-tetO-WT in 7H9 medium with 400 ng/ml atc, until the OD reached 0.5~0.6. Then Mtb was washed with 7H9 medium 3 times and suspended in 7H9 medium with or without atc. Then samples were taken 24, 48, 72 and 120 hrs later.
 
Contributor(s) Lin K, Ehrt S
Citation(s) 27249779
Submission date Aug 24, 2015
Last update date Jun 02, 2016
Contact name Kan Lin
E-mail(s) kal2025@med.cornell.edu
Organization name Weill Cornell Medical College
Department Microbiology and Immunology
Lab Dr. Sabine Ehrt
Street address 413 East 69th Street
City NEW YORK
State/province New York
ZIP/Postal code 10021
Country USA
 
Platforms (1)
GPL16177 Agilent-019943 Genotypic Technology custom M tuberculosis h37Rv Whole Genome 8x15k GE Microarray [Gene Name version]
Samples (9)
GSM1860252 TrxB2-TetON-tetO-WT_atc_0hr
GSM1860253 TrxB2-TetON-tetO-WT_atc_24hr
GSM1860254 TrxB2-TetON-tetO-WT_atc_48hr
This SubSeries is part of SuperSeries:
GSE72330 Comparison of gene expression in M. tuberculosis TrxB2 mutants
Relations
BioProject PRJNA293753

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE72328_RAW.tar 20.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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