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Series GSE72545 Query DataSets for GSE72545
Status Public on Nov 29, 2016
Title Integrin-α10-dependency defines a novel therapeutic strategy targeting RAC and mTORC2 for metastatic myxofibrosarcoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Analysis of U133A microarray data from 64 primary high-grade myxofibrosarcoma tumors identified ITGA10 as the gene most significantly associated with distant metastasis and poor disease-specific survival.
Further investigation using shRNA knockdown identifies the TRIO-RAC-PAK and RICTOR-mTORC2 pathways as important downstream signaling pathways for ITGA10.
 
Overall design RNA samples were prepared from 64 primary high-grade myxofibrosarcoma tumors previously frozen in liquid nitrogen. A portion of each tumor was placed in a cryomold and slides were cut for review by our pathologist to confirm the diagnosis in each case. Areas of normal tissue and necrotic tumor were macrodissected based on slide review. Only areas of viable tumor were included for RNA extraction.
 
Contributor(s) Lee AY, Okada T, Agaram N, Qin L, Socci ND, Miller M, Agius P, Molinelli E, Tap W, Crago A, Sander C, Decarolis P, Shen Y, O'Connor R, Singer S
Citation(s) 27577794
Submission date Aug 31, 2015
Last update date Sep 16, 2019
Contact name Jeffrey Zhao
Organization name Memorial Sloan Kettering Cancer Center
Department Genomics Core
Street address 1275 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (64)
GSM1864863 high-grade primary myxofibrosarcoma 0224
GSM1864864 high-grade primary myxofibrosarcoma 1041
GSM1864865 high-grade primary myxofibrosarcoma 2516
Relations
BioProject PRJNA294304

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE72545_HG_MXF_64_Deidentified_clinical_data.txt.gz 2.3 Kb (ftp)(http) TXT
GSE72545_RAW.tar 176.2 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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