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| Status |
Public on May 02, 2007 |
| Title |
profiling of hypothalamus from arthritic DBA/1 mice vs. control DBA/1 mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Using microarrays we studied the gene expression profile of the hypothalamus in DBA/1 mice strain that developed collagen induced-arthritis vs control mice.
Keywords: gene expression profile of the hypothalamus in response to induction of arthritis
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| Overall design |
We used two-color oligonucleotides in-house printed microarrays in a case-control direct design with two technical replicates in a dye swap design. We analyze changes in gene expression profile in the hypothalamus of arthritic vs control mice. We performed 3 samples (biological replicates)
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| Contributor(s) |
Salibe MC, Alvarez MJ, Serra CG, Celi DC, Vila-Ortiz G, Ramirez A, Podhajcer OL, Pitossi FJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Mar 15, 2007 |
| Last update date |
Mar 19, 2012 |
| Contact name |
Mariano Cesar Salibe |
| E-mail(s) |
msalibe@leloir.org.ar
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| Organization name |
Gentron LLC
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| Street address |
Av. Patricias Argentinas 435
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| City |
Ciudad de Buenos Aires |
| ZIP/Postal code |
1425 |
| Country |
Argentina |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE7565 |
Profiling brain and liver tissues from mice |
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| Relations |
| BioProject |
PRJNA105037 |
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