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| Status |
Public on Aug 17, 2017 |
| Title |
Molecular subtypes of metastatic colorectal cancer are predictive of patient response to chemo and targeted therapies (part 2) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We report that previously described molecular subtypes of colorectal cancer are associated with the response to therapy in patients with metastatic disease. We also identified a patient population with high FOLFIRI sensitivity, as indicated by their 2.7-fold longer overall survival when treated with FOLFIRI, as first-line regimen, instead of FOLFOX. Our results demonstrate the interest of molecular classifications to develop tailored therapies for patients with metastatic colorectal cancer.
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| Overall design |
The COSIVAL cohort was a retrospective multicenter study involving 6 French hospitals (CHU Trousseau - Tours, Hôpital Purpan - Toulouse, Hôpital Central - Nancy, Hôpital Dupuytren - Limoges, Hôpital Ambroise Paré – Boulogne Billancourt, Hopital de Lille ) and 2 comprehensive Cancer Centers (ICM, Montpellier; Institut Bergonié, Bordeaux) and contained 68 patients
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| Contributor(s) |
Del Rio M, Mollevi C, Martineau P |
| Citation(s) |
28284171, 28659146, 30863148 |
| |
| Submission date |
Sep 12, 2015 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Pierre Martineau |
| E-mail(s) |
pierre.martineau@inserm.fr
|
| Phone |
+33 4 67 61 37 43
|
| Organization name |
Inserm
|
| Department |
IRCM
|
| Street address |
208 Rue des Apothicaires
|
| City |
Montpellier Cedex 5 |
| ZIP/Postal code |
34298 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (56)
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| This SubSeries is part of SuperSeries: |
| GSE72970 |
Molecular subtypes of metastatic colorectal cancer are predictive of patient response to chemo and targeted therapies |
|
| Relations |
| BioProject |
PRJNA295465 |
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