|
| Status |
Public on Apr 02, 2007 |
| Title |
Expression data from age-dichotomized ER+, N0 breast tumors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen.
In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic significance are identified in a largely TAM-treated set of ER+ node negative breast cancers. The prognostic value with respect to age is also investigated.
Keywords: biomarker identification
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| |
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| Overall design |
54 ER+ node negative breast tumors with known clinical outcome were analyzed. Genes co-ordinately regulated by NFKB and AP1from literature are identified from a significant gene set obtained through a minimum variation filter. Biomarker expression is used to dichotomize samples into high vs. low expressors to determine prognostic value
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| |
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| Contributor(s) |
Zhou Y, Yau C, Gray JW, Chew K, Dairkee SH, Moore DH, Benz CC |
| Citation(s) |
17407600, 18631401 |
| |
| Submission date |
Mar 27, 2007 |
| Last update date |
Mar 28, 2013 |
| Contact name |
Christina Yau |
| E-mail(s) |
cyau@buckinstitute.org
|
| Phone |
415-209-2248
|
| Organization name |
Buck Institute of Age Research
|
| Lab |
Benz Lab
|
| Street address |
8001 Redwood Blvd
|
| City |
Novato |
| State/province |
CA |
| ZIP/Postal code |
94945 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL4685 |
[U133AAofAv2] Affymetrix GeneChip HT-HG_U133A Early Access Array |
|
| Samples (54)
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| Relations |
| BioProject |
PRJNA100413 |
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