|
| Status |
Public on Oct 16, 2015 |
| Title |
Transcriptome Analysis Identifies Linc-Yy1, A Novel Functional LincRNA During Myogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery of a novel lincRNA, Linc-YY1 from the promoter of transcription factor (TF) Yin Yang 1 (YY1) gene. We demonstrate that Linc-YY1 is dynamically regulated during myogenesis in vitro and in vivo. Gain or loss of function of Linc-YY1 in C2C12 myoblast cells or satellite cells alters myogenic differentiation and in injured muscles impacts the course of regeneration. Further studies suggest LincYY1 may interact with YY1 through its middle domain to evict YY1
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| |
|
| Overall design |
9 ChIP-seq and 4 RNA-seq experiments performed
|
| |
|
| Contributor(s) |
Wang H, Sun H, Zhou L, Sun K, Zhao Y |
| Citation(s) |
26658965, 26981420 |
| |
| Submission date |
Oct 15, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Kun Sun |
| E-mail(s) |
sunkun@szbl.ac.cn
|
| Organization name |
Shenzhen Bay Laboratory
|
| Department |
Cancer Research
|
| Lab |
Kun Sun
|
| Street address |
Rm B505, No. 9 Duxue Road, Nanshan District
|
| City |
Shenzhen |
| ZIP/Postal code |
518107 |
| Country |
China |
| |
|
| Platforms (3) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
| GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
|
| Samples (13)
|
|
| Relations |
| BioProject |
PRJNA298863 |
| SRA |
SRP064842 |
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