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| Status |
Public on Apr 20, 2016 |
| Title |
IFN type I-induced gene expression from brain endothelia |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Brain endothelial cells are an essential part of the blood-brain-barrier (BBB) and, as such, are exposed to proinflammatory mediators as well as danger signals during infections. They might function as decisive cells mediating RNA virus- and IFN-mediated sickness behavior.
To better understand how brain endothelial cells modulate sickness behavior associated with virus-induced IFN release, we challenged endothelia with IFNbeta and investigated the transcription profile after IFNAR1 engagement
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| Overall design |
Cultured brain endothelia isolated from adult mice were incubated with IFNbeta; 24h later cells were removed for RNA extraction and hybridization on Affymetrix arrays.
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| Contributor(s) |
Spiess A, Staszewski O |
| Citation(s) |
27096319 |
| |
| Submission date |
Oct 15, 2015 |
| Last update date |
Mar 08, 2018 |
| Contact name |
Ori Staszewski |
| E-mail(s) |
ori.staszewski@uniklinik-freiburg.de
|
| Organization name |
University Medical Center Freiburg
|
| Department |
Institute of Neuropathology
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| Street address |
Breisacher Str. 64
|
| City |
Freiburg |
| ZIP/Postal code |
D-79106 |
| Country |
Germany |
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| Platforms (1) |
| GPL17400 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE74063 |
Brain Endothelial Specific IFNAR Is Key For Virus-Induced Sickness Behavior And Cognitive Impairment |
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| Relations |
| BioProject |
PRJNA298890 |
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