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| Status |
Public on Oct 30, 2015 |
| Title |
Expression data from three types of spermatogonial stem cells. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Multipotent spermatogonial stem cells (mSSCs) derived from SSCs are a potential new source of individualized pluripotent cells in regenerate medicine such as ESCs. We hypothesized that the culture-induced reprogramming of SSCs was mediated by a mechanism different from that of iPS, and was due to up-regulation of specific pluripotency-related genes during cultivation. Through a comparative analysis of expression profile data, we try to find cell reprogramming candidate factors from mouse spermatogonial stem cells. We used microarrays to analyze the gene expression profiles of culture-induced reprogramming converting unipotent spermatogonial stem cells to pluripotent spermatogonial stem cells.
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| Overall design |
Three types of spermatogonial stem cells were mechanically collected according to morphological criteria for RNA extraction and hybridization on Affymetrix microarrays.
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| |
|
| Contributor(s) |
Lee DR, Lee I |
| Citation(s) |
26740582 |
| |
| Submission date |
Oct 19, 2015 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Boyoun Park |
| E-mail(s) |
bypark@yonsei.ac.kr
|
| Organization name |
Yonsei University
|
| Department |
Systems biology
|
| Street address |
50 Yonsei-ro, Seodaemun-gu
|
| City |
Seoul |
| ZIP/Postal code |
120-749 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE74156 |
An integrated systems biology approach identifies positive cofactor 4 as a pluripotency regulatory factor |
|
| Relations |
| BioProject |
PRJNA299186 |
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