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Status |
Public on Nov 04, 2015 |
Title |
Bortezomib resistance in CCRF-CEM cell line [GEP] |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the CCRF-CEM T-ALL cell line. On these subclones comparative Genome hybridization (arrayCGH) for DNA copy number analysis gene expression and micro-RNA expression arrays were performed.
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Overall design |
We performed gene expression microarray analysis on four different bortezomib resistant subclones of the CCRF-CEM cell line. The resistant subclones were compaired to treated and untreated the parental CCRF-CEM wildtype cell line.
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Contributor(s) |
Franke NE, Kaspers GL, Assaraf YG, van Meerloo J, Niewerth D, Kessler FL, Poddighe PJ, Smeets S, Ylstra B, Bi C, Chng WJ, Horton TM, Menezes RX, Musters RJ, Zweegman S, Jansen G, Cloos J |
Citation missing |
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Submission date |
Nov 03, 2015 |
Last update date |
Feb 22, 2018 |
Contact name |
Daoud Sie |
E-mail(s) |
d.sie@vumc.nl
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Phone |
+31 20 4442428
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Organization name |
Vrije Universiteit Medical Center
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Department |
Pathology
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Lab |
Microarray Core Facility
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Street address |
De Boelelaan 1117
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City |
Amsterdam |
ZIP/Postal code |
1081 HV |
Country |
Netherlands |
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Platforms (1) |
GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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Samples (11)
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This SubSeries is part of SuperSeries: |
GSE74635 |
Bortezomib resistance in CCRF-CEM cell line |
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Relations |
BioProject |
PRJNA301042 |