|
| Status |
Public on Jan 10, 2016 |
| Title |
Functional dissection of Drosophila melanogasterSUUR protein influence on H3K27me3 profile |
| Organism |
Drosophila melanogaster |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
In eukaryotes, heterochromatin replicates late in S phase of the cell cycle and contains specific covalent modifications of histones. SuURmutation found in Drosophila makes heterochromatin replicate earlier than in wild type and reduces the level of repressive histone modifications. SUUR protein was shown to be associated with moving replication forks, apparently through the interaction with PCNA. The biological process underlying the effects of SUUR on replication and composition of heterochromatin remains unknown.
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| |
|
| Overall design |
Examination of H3K27me3 histone modification in Drosophila embryos in presence or absence of SuUR mutation.
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| |
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| Contributor(s) |
Posukh OV, Belyakin SN, Laktionov PP, Maksimov DA, Koryakov DE |
| Citation(s) |
29191233 |
| |
| Submission date |
Nov 11, 2015 |
| Last update date |
Oct 29, 2019 |
| Contact name |
Daniil Maksimov |
| E-mail(s) |
vift@mail.ru
|
| Organization name |
MCB NSC RAS
|
| Lab |
Genomics lab
|
| Street address |
Lavrentjeva ave., 8/2
|
| City |
Novosibirsk |
| ZIP/Postal code |
630090 |
| Country |
Russia |
| |
|
| Platforms (1) |
| GPL16479 |
Illumina MiSeq (Drosophila melanogaster) |
|
| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE74909 |
Repressive Histone Marks Renewal Impedes Replication Fork Progression and Contributes To Late Replication in Drosophila |
|
| Relations |
| BioProject |
PRJNA301886 |
| SRA |
SRP066050 |
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