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Series GSE7527 Query DataSets for GSE7527
Status Public on May 12, 2008
Title Array CGH in congenital heart disease
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Congenital heart disease (CHD) is the most frequent birth defect and affects nearly 1% of newborns. The etiology of CHD is largely unknown and only a small percentage can be assigned to environmental risk factors such as maternal diseases or exposure to mutagenic agents during pregnancy. Chromosomal imbalances have been identified in many forms of syndromic CHD, but next to nothing is known about the impact of DNA copy number changes in non-syndromic CHD. Here we present a sub-megabase resolution array CGH screen of a cohort with CHD as the sole abnormality at the time of diagnosis.
Keywords: array CGH
 
Overall design In this BAC array CGH study 104 patients with congenital heart disease and some of their parents were screened for DNA copy number changes at submegabase resolution. No dye swap was performed.
 
Contributor(s) Erdogan F
Citation(s) 18713793
Submission date Apr 16, 2007
Last update date Mar 16, 2012
Contact name Fikret Erdogan
E-mail(s) erdogan@molgen.mpg.de
Organization name Max-Planck-Institute
Street address Ihnestr. 73
City Berlin
ZIP/Postal code 14195
Country Germany
 
Platforms (2)
GPL5000 MPIMG Homo sapiens 44K ArrayCGH4
GPL5114 MPIMG Homo sapiens 36k_arrayCGH8
Samples (119)
GSM175540 CHD Patient 1988
GSM182163 CHD Patient 1553
GSM182164 CHD Patient 1559
Relations
BioProject PRJNA99395

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7527_RAW.tar 372.3 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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