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| Status |
Public on May 24, 2017 |
| Title |
Transcriptional network controlled by Candida glabrata Ada2, a transcription coactivator |
| Organism |
Nakaseomyces glabratus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In order to identify genes governed by Ada2, a transcription coactivator in C. glabrata, we compared the genome-wide expression profile in wild-type strain CBS138 and ada2 mutant via RNA sequencing. According to our analyses, 43 genes were down- and 443 genes were up-regulated in ada2 mutant when compared with the wild-type. The 43 down-regulated genes involved in ergosterol biosynthesis pathway (ERG6, ERG13), adhesin or adhesin-like genes (ICS2, AWP2, EPA7), heat shock genes (HSP30, SSB2) and other cellular functions. Among the 443 up-regulated genes, nine adhesin-like EPA family genes (EPA1, EPA6, EPA8, EPA10, EPA11, EPA12, EPA15, EPA20, EPA23) and three yapsin family genes (YPS4, YPS8, YPS10) were included.
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| Overall design |
Total mRNAs extracted from C. glabrata wild-type CBS138 and ada2 mutant were analyzed using RNA sequencing
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| Contributor(s) |
Yu S, Chen Y |
| Citation(s) |
29311082 |
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| Submission date |
Dec 24, 2015 |
| Last update date |
Mar 16, 2020 |
| Contact name |
Shang Jie Yu |
| E-mail(s) |
r02633017@ntu.edu.tw
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| Phone |
+886978719501
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| Organization name |
National Taiwan University
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| Department |
Plant Pathology and Microbiology
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| Lab |
Applied Microbiology Lab.
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| Street address |
No. 1, Sec. 4, Roosevelt Rd
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| City |
Taipei city |
| State/province |
Taiwan (R.O.C) |
| ZIP/Postal code |
10671 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL19215 |
Illumina HiSeq 2000 (Candida glabrata) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA306939 |
| SRA |
SRP067778 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE76338_RAW.tar |
720.0 Kb |
(http)(custom) |
TAR (of TXT) |
| GSE76338_WT-VS-YSJ4.GeneDiffExp.txt.gz |
482.2 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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