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| Status |
Public on Aug 10, 2016 |
| Title |
Gene expression signatures for murine alveolar type II lung epithelial cells after tumor bearing |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To determine the influence of primary tumors on pre-metastatic lungs, we have employed whole genome microarray expression profiling as a discovery platform to identify gene signatures of alveolar type II epithelial cells (AT-II) in TLR3 deficient mice (Tlr3-/-) and wide-type (WT) littermates with tumor bearing. We subcutaneously inoculated Tlr3-/- and WT mice with Lewis lung carcinoma (LLC). Two weeks later, lung tissues from Tlr3-/- and WT mice were dissociated and AT-II cells were sorted. AT-II cells from mice without tumor bearing were set as controls.
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| Overall design |
Primary tumor induced gene expression in AT-II cells from Tlr3-/- and WT mice was measured at 2 weeks after tumor inoculation subcutaneously. AT-II cells from mice without tumor bearing were set as controls.
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| Contributor(s) |
Cao X, Liu Y |
| Citation(s) |
27505671 |
| |
| Submission date |
Dec 29, 2015 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Liu Yanfang |
| E-mail(s) |
liuyanfang00215@163.com
|
| Phone |
0086-13918386805
|
| Organization name |
Second Military Medical University
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| Department |
Immunology
|
| Street address |
800 Xiangyin Road
|
| City |
Shanghai |
| ZIP/Postal code |
200433 |
| Country |
China |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA307182 |
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