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Series GSE76397 Query DataSets for GSE76397
Status Public on Aug 10, 2016
Title Gene expression signatures for murine alveolar type II lung epithelial cells after tumor bearing
Organism Mus musculus
Experiment type Expression profiling by array
Summary To determine the influence of primary tumors on pre-metastatic lungs, we have employed whole genome microarray expression profiling as a discovery platform to identify gene signatures of alveolar type II epithelial cells (AT-II) in TLR3 deficient mice (Tlr3-/-) and wide-type (WT) littermates with tumor bearing. We subcutaneously inoculated Tlr3-/- and WT mice with Lewis lung carcinoma (LLC). Two weeks later, lung tissues from Tlr3-/- and WT mice were dissociated and AT-II cells were sorted. AT-II cells from mice without tumor bearing were set as controls.
Overall design Primary tumor induced gene expression in AT-II cells from Tlr3-/- and WT mice was measured at 2 weeks after tumor inoculation subcutaneously. AT-II cells from mice without tumor bearing were set as controls.
Contributor(s) Cao X, Liu Y
Citation(s) 27505671
Submission date Dec 29, 2015
Last update date Jan 12, 2017
Contact name Liu Yanfang
Phone 0086-13918386805
Organization name Second Military Medical University
Department Immunology
Street address 800 Xiangyin Road
City Shanghai
ZIP/Postal code 200433
Country China
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (4)
GSM1986064 AT-II_WT_normal
GSM1986065 AT-II_WT_tumor
GSM1986066 AT-II_Tlr3 deficient_normal
BioProject PRJNA307182

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Supplementary file Size Download File type/resource
GSE76397_RAW.tar 34.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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