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| Status |
Public on Sep 07, 2016 |
| Title |
Effect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TCM) |
| Platform organism |
Homo sapiens |
| Sample organism |
Macaca mulatta |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in changes to T and/or NK cell population dynamics that would reflect physiologic IL-15 function. The results provide important information on the specific role IL-15 plays in effector memory T cell and NK cell homeostasis, noting that effector memory T cells but not NK cells can be maintained in the absence of IL-15 signaling by the activity of other cytokines.
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| |
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| Overall design |
Sort-purified CD8+ and CD4+ TCM from PBMC, before and after treatment with IgG1 Ab and anti-IL15 Ab
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| |
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| Contributor(s) |
DeGottardi MQ, Okoye AA, Vaidya M, Talla A, Sekaly R, Picker LJ |
| Citation(s) |
27430715 |
| |
| Submission date |
Jan 12, 2016 |
| Last update date |
Aug 13, 2018 |
| Contact name |
AARTHI TALLA |
| E-mail(s) |
axt427@case.edu
|
| Phone |
4047695226
|
| Organization name |
Case Western Reserve University School of Medicine
|
| Department |
Pathology
|
| Lab |
Dr.Rafick Sekaly
|
| Street address |
2103 Cornell Rd
|
| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44106 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (49)
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| This SubSeries is part of SuperSeries: |
| GSE76797 |
Effect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques |
|
| Relations |
| BioProject |
PRJNA308589 |
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