|
| Status |
Public on Oct 09, 2018 |
| Title |
Manganese (II) Activates cGAS-STING pathway |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We show that Manganese (II) is a potent type I-IFN inducing agonist, stimulating cells into an anti-viral state in the absence of infection. Mechanically, Mn2+ treatment led to a profound cGAS-STING-dependent innate immune activation, conferring cells or mice viral resistance.
|
| |
|
| Overall design |
THP1 cells were treated with Mn2+, VACV, IFNβ or empty media (control). RNA was extracted and sequenced.
|
| |
|
| Contributor(s) |
Jiang Z, Guan Y |
| Citation(s) |
29653696 |
| |
| Submission date |
Jan 26, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Yukun Guan |
| E-mail(s) |
yukun.guan@nih.gov
|
| Organization name |
NIAAA
|
| Lab |
LLD
|
| Street address |
5625 Fishers Lane, Room 2S-30
|
| City |
Rockville |
| State/province |
MD |
| ZIP/Postal code |
20852 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA309759 |
| SRA |
SRP068909 |
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