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Status |
Public on Oct 09, 2018 |
Title |
Manganese (II) Activates cGAS-STING pathway |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
We show that Manganese (II) is a potent type I-IFN inducing agonist, stimulating cells into an anti-viral state in the absence of infection. Mechanically, Mn2+ treatment led to a profound cGAS-STING-dependent innate immune activation, conferring cells or mice viral resistance.
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Overall design |
THP1 cells were treated with Mn2+, VACV, IFNβ or empty media (control). RNA was extracted and sequenced.
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Contributor(s) |
Jiang Z, Guan Y |
Citation(s) |
29653696 |
|
Submission date |
Jan 26, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Yukun Guan |
E-mail(s) |
yukun.guan@nih.gov
|
Organization name |
NIAAA
|
Lab |
LLD
|
Street address |
5625 Fishers Lane, Room 2S-30
|
City |
Rockville |
State/province |
MD |
ZIP/Postal code |
20852 |
Country |
USA |
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Platforms (1) |
GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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Samples (4)
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Relations |
BioProject |
PRJNA309759 |
SRA |
SRP068909 |