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| Status |
Public on Nov 02, 2016 |
| Title |
Irf3 phenotyping |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The interferon regulatory factors IRF3 and IRF7 are key players in the regulation of type I and III IFN genes. In this study, we analyzed the role of IRF3 and IRF7 for the host response to influenza A virus infections in Irf3-/-, Irf7-/- and Irf3-/-Irf7-/- knock-out mice.
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| Overall design |
The KO and WT mice were intranasally infected with PR8M virus or PBS for mock controls. Lungs were collected at indicated time points post infection (d3) . Total RNA from these lungs were used for microarray analysis.
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| Contributor(s) |
Schughardt K, Hatesuer B, Geffers R, Hoang H, Wilk E |
| Citation(s) |
27811478 |
| |
| Submission date |
Feb 05, 2016 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Robert Geffers |
| E-mail(s) |
robert.geffers@helmholtz-hzi.de
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| Phone |
+49 531-6181-3058
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| Organization name |
HCI - Helmholtz Centre for Infection Research
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| Department |
Dep. Molecular Bacteriology
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| Lab |
Genome Analytics
|
| Street address |
Inhoffenstr. 7
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| City |
Braunschweig |
| ZIP/Postal code |
38124 |
| Country |
Germany |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA310995 |
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