|
Status |
Public on Dec 01, 2021 |
Title |
Loss of PD-1 aggravates plaque pathology by disrupting microglial phagocytosis in APP/PS1 mice |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
Astrocytic secretion of soluble B7-H1 and subsequent engagement with microglial PD-1 regulates microglial clearance of Ab by modulating the expression of CD36.
|
|
|
Overall design |
Wild type and PD-1 KO mice brains at 0, 2, and 8 hours. Some treated with Amyloid-beta and some without.
|
|
|
Contributor(s) |
Schultze JL, Klee K, Beyer M |
Citation(s) |
34825707 |
|
Submission date |
Feb 05, 2016 |
Last update date |
Dec 01, 2021 |
Contact name |
Joachim Schultze |
E-mail(s) |
j.schultze@uni-bonn.de
|
Organization name |
LIMES (Life and Medical Sciences Center Genomics and Immunoregulation)
|
Department |
Genomics and Immunoregulation
|
Street address |
Carl-Troll-Strasse 31
|
City |
Bonn |
State/province |
NRW |
ZIP/Postal code |
53115 |
Country |
Germany |
|
|
Platforms (1) |
GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
|
Samples (30)
|
|
Relations |
BioProject |
PRJNA311075 |
SRA |
SRP069725 |