|
| Status |
Public on Dec 01, 2021 |
| Title |
Loss of PD-1 aggravates plaque pathology by disrupting microglial phagocytosis in APP/PS1 mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Astrocytic secretion of soluble B7-H1 and subsequent engagement with microglial PD-1 regulates microglial clearance of Ab by modulating the expression of CD36.
|
| |
|
| Overall design |
Wild type and PD-1 KO mice brains at 0, 2, and 8 hours. Some treated with Amyloid-beta and some without.
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| |
|
| Contributor(s) |
Schultze JL, Klee K, Beyer M |
| Citation(s) |
34825707 |
| |
| Submission date |
Feb 05, 2016 |
| Last update date |
Dec 01, 2021 |
| Contact name |
Joachim Schultze |
| E-mail(s) |
j.schultze@uni-bonn.de
|
| Organization name |
LIMES (Life and Medical Sciences Center Genomics and Immunoregulation)
|
| Department |
Genomics and Immunoregulation
|
| Street address |
Carl-Troll-Strasse 31
|
| City |
Bonn |
| State/province |
NRW |
| ZIP/Postal code |
53115 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
|
| Samples (30)
|
|
| Relations |
| BioProject |
PRJNA311075 |
| SRA |
SRP069725 |
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