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| Status |
Public on Sep 01, 2017 |
| Title |
Effect of Imatinib (1microM, 24 hours) on the microRNA repertoire of chronic myeloid leukemia cell line K562 |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Using a microarray-based miRNA profiling, we found in a model of chronic myeloid leukemia (CML) that the activity of the oncoprotein BCR-ABL1 regulates the expression of miR-21, a "onco-microRNA" known to be overexpressed in numerous cancers. This relies on the phosphorylation status of STAT5, a transcription factor known to be activated by the kinase activity of BCR-ABL1. Mir-21 regulates the expression of PDCD4 (programmed cell death protein 4), a tumor suppressor identified here through a proteomics approach
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| Overall design |
The microRNA repertoire of K562 cells having been either not treated (n=3) or treated (n=3) with the tyrosine kinase inhibitor Imatinib (1microM, 24h) was studied using Agilent microRNA V2 microarrays
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| Contributor(s) |
Cardinaud B |
| Citation(s) |
29100302 |
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| Submission date |
Feb 17, 2016 |
| Last update date |
Dec 01, 2017 |
| Contact name |
Bruno CARDINAUD |
| E-mail(s) |
bruno.cardinaud@u-bordeaux.fr
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| Organization name |
Bordeaux University
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| Department |
INSERM U1035
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| Street address |
146 rue Leo Saignat
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| City |
BORDEAUX |
| ZIP/Postal code |
33076 |
| Country |
France |
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| Platforms (1) |
| GPL7731 |
Agilent-019118 Human miRNA Microarray 2.0 G4470B (Feature Number version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA312395 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE78037_RAW.tar |
10.8 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE78037_quantile_normalized.txt.gz |
5.7 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
| Processed data provided as supplementary file |
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