|
| Status |
Public on Apr 21, 2016 |
| Title |
Epigenetic Profiles Signify Cell Fate Plasticity in Unipotent Spermatogonial Stem and Progenitor Cells (ChIP-Seq) |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Mammalian spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs) during in vitro expansion. Here, we examine the epigenetic signature of SSCs and MASCs, identifying bivalent histone H3-lysine4 and -lysine27 trimethylation at somatic gene promoters in SSCs and an ESC-like promoter chromatin state in MASCs.
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| |
|
| Overall design |
Examination of histone modifications K4me3, K27me3, and K27ac in different cell types.
|
| |
|
| Contributor(s) |
Liu Y, Rafii S |
| Citation(s) |
27117588 |
| |
| Submission date |
Feb 19, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Ying Liu |
| E-mail(s) |
yil2004@med.cornell.edu
|
| Organization name |
Weill Cornell Medical College
|
| Department |
Medicine
|
| Street address |
1300 York Ave
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10021 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL15103 |
Illumina HiSeq 1000 (Mus musculus) |
|
| Samples (33)
|
|
| Relations |
| BioProject |
PRJNA312674 |
| SRA |
SRP070585 |
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