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| Status |
Public on May 23, 2007 |
| Title |
Effect of acute creatine monohydrate supplementation on skeletal muscle transcriptome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Expression profiling of vastus lateralis muscle of young, healthy, non-obese men supplemented with creatine monohydrate vs. placebo for 10 days. Results identify transcriptional pathways activated in skeletal muscles as a result of acute creatine monohydrate supplementation.
Keywords: Supplementation response.
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| Overall design |
In a randomized, placebo-controlled, crossover, double-blind design, 12 young, healthy, non-obese men were supplemented with either a placebo or creatine monohydrate (loading phase, 20 g/d x 3 d; maintenance phase, 5 g/d x 7 d) for 10 d. Following a 28 day washout period, subjects were put on the alternate supplementation for 10 days. Muscle biopsies of the vastus lateralis were obtained and were assessed for global mRNA expression using cDNA microarrays.
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| Contributor(s) |
Safdar A, Yardley N, Snow R, Melov S, Tarnopolsky MA |
| Citation(s) |
17957000 |
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| Submission date |
May 23, 2007 |
| Last update date |
Jan 17, 2013 |
| Contact name |
Adeel Safdar |
| E-mail(s) |
safdars@mcmaster.ca
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| Phone |
905-525-9140
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| Fax |
905-577-8380
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| Organization name |
McMaster University
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| Department |
Kinesiology
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| Street address |
1200 Main Street West
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| City |
Hamilton |
| State/province |
ON |
| ZIP/Postal code |
L8N3Z5 |
| Country |
Canada |
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| Platforms (1) |
| GPL5216 |
Buck Institute_Homo sapiens_25K_verC |
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| Samples (12)
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| GSM190997 |
Young Men_Creatine Monohydrate Supplementation_subject1 |
| GSM190998 |
Young Men_Creatine Monohydrate Supplementation_subject2 |
| GSM190999 |
Young Men_Creatine Monohydrate Supplementation_subject3 |
| GSM191000 |
Young Men_Creatine Monohydrate Supplementation_subject4 |
| GSM191001 |
Young Men_Creatine Monohydrate Supplementation_subject5 |
| GSM191002 |
Young Men_Creatine Monohydrate Supplementation_subject6 |
| GSM191003 |
Young Men_Creatine Monohydrate Supplementation_subject7 |
| GSM191004 |
Young Men_Creatine Monohydrate Supplementation_subject8 |
| GSM191005 |
Young Men_Creatine Monohydrate Supplementation_subject9 |
| GSM191006 |
Young Men_Creatine Monohydrate Supplementation_subject10 |
| GSM191007 |
Young Men_Creatine Monohydrate Supplementation_subject11 |
| GSM191008 |
Young Men_Creatine Monohydrate Supplementation_subject12 |
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| Relations |
| BioProject |
PRJNA99905 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE7877_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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