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| Status |
Public on May 30, 2016 |
| Title |
Expression data from melanosis coli (MC) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
There is still a big debate about the correlation between melanosis coli (MC) and carcinoma. We used HTA2.0 to investigate the expression changes of lncRNAs and mRNAs in human colonic mucosa with or without MC and try to investigate MC from gene aspect, eventually to demonstrate whether there’s a certain correlation between MC and carcinoma.
GeneChip® Human Transcriptome Array 2.0 (HTA 2.0) microarrays were adopted. The expression profile of lncRNAs and mRNA were tested in five colon tissue biopsy specimen of MC patients and five demographically-matched controls.
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| Overall design |
This study recruited a total of five MC patients and five coupled matched controls. All specimens were obtained from colonoscopy. The fresh specimens of colon tissues form MC patients and control patients were washed with RNAase free water and put into RNAlater (Qiagen) immediately and frozen in -80°C. Gene Ontology (GO) and KEGG Pathway analyses of aberrantly expressed mRNAs were performed to identify the related biological functions and pathologic pathways.
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| Contributor(s) |
Wang S, Fan Y, Lv B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 07, 2016 |
| Last update date |
Oct 29, 2018 |
| Contact name |
Shiyi Wang |
| E-mail(s) |
wangshiyi26@126.com
|
| Phone |
+86 15088662042
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| Organization name |
The First Affiliated Hospital of Zhejiang Chinese Medical University
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| Department |
Department of Gastroenterology
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| Street address |
No. 54, Youdian Road
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| City |
Hangzhou |
| State/province |
Zhejiang Province |
| ZIP/Postal code |
310006 |
| Country |
China |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA314456 |
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