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Status |
Public on May 02, 2018 |
Title |
Characterization of a spontaneous model of inflammation-derived liver cancer [ChIP-seq] |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
Induction of a protective response to oxidative stress, both from a transcriptional and from a genetic viewpoint, confers a selective advantage for cells exposed to an inflammatory environment, paving the way to neoplastic transformation
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Overall design |
Chromatin immuno-precipitations of acetylated lysine 27 of H3 followed by multiparallel sequencing, performed on tissues of Mdr2-WT (FVB.129P2) livers, Mdr2-KO (FVB.129P2-Abcb4tm1Bor/J) inflamed livers or hepatocarcinoma nodules from Mdr2-KO livers. All samples have been treated with clodronate liposomes to prevent sample contamination by liver macrophages
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Contributor(s) |
Collino A, Ghisletti S, Termanini A, Natoli G |
Citation(s) |
29734330 |
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Submission date |
Apr 28, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Alberto Termanini |
E-mail(s) |
termanini@me.com
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Organization name |
Istituto Clinico Humanitas
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Lab |
Bioinformatic Unit
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Street address |
Via Manzoni, 113
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City |
Rozzano |
State/province |
MI |
ZIP/Postal code |
20089 |
Country |
Italy |
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Platforms (1) |
GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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Samples (16)
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This SubSeries is part of SuperSeries: |
GSE80777 |
Characterization of a spontaneous model of inflammation-derived liver cancer |
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Relations |
BioProject |
PRJNA319967 |
SRA |
SRP074135 |