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| Status |
Public on Mar 21, 2018 |
| Title |
Gene expression from human keratinocytes isolated from limited systemic sclerosis (lcSSc) and diffuse systemic sclerosis (dcSSc) skin biopsy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Systemic sclerosis (SSc) is a rare but devastating disease of fibrosis impacting the dermis and multiple organ systems. The prevalence ranges from 4 to 489 cases per million individuals with ten year mortality rates reported around 18 percent. Survival is related to the extent of skin involvement, yet the precise mechanisms driving skin fibrosis in SSc remain unknown. In this study, we analyzed the shared and unique transcriptomic profiles of SSc and normal keratinocytes.
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| Overall design |
RNA from keratinocytes isolated and grown to passage 2 from human skin biopsies was extracted and processed for hybridization on Affymetrix microarrays.
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| Contributor(s) |
McCoy SS, Reed TJ, Berthier CC, Tsou PS, Khanna D, Gudjonsson JE, Kahlenberg JM |
| Citation(s) |
28968684 |
| |
| Submission date |
May 03, 2016 |
| Last update date |
Mar 21, 2018 |
| Contact name |
Celine C Berthier |
| Organization name |
University of Michigan
|
| Street address |
1150 W. Medical Center Dr, MSRB2
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
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| Platforms (1) |
| GPL17692 |
[HuGene-2_1-st] Affymetrix Human Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA320417 |
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