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| Status |
Public on Mar 07, 2017 |
| Title |
Genome-wide maps of histone variant H3.3 occupancy in zebrafish cardiomyocytes [H3K27Ac] |
| Organism |
Danio rerio |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We report high-throughput profiling of acetylation of lysine 27 on histone H3 from whole zebrafish ventricles. The H3K27Ac mark has been shown to be present at active enhancer elements and including regions of active chromatin. We profile H3K27Ac in uninjured cardiomyocytes and those undergoing regeneration 14 days after genetic ablation. This study provides a framework for understanding chromatin transitions during adult models of regeneration.
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| Overall design |
Examination of H3K27Ac occupancy in uninjured cardiomyocytes and those undergoing regeneration 14 days after genetic ablation
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| Contributor(s) |
Goldman JA, Kuzu G, Lee N, Karasik J, Gemberling M, Karra R, Dickson A, Sun F, Foglia MJ, Tolstorukov M, Poss KD |
| Citation(s) |
28245924 |
| |
| Submission date |
May 25, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Michael Tolstorukov |
| E-mail(s) |
tolstorukov@molbio.mgh.harvard.edu
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| Organization name |
Massachusetts General Hospital
|
| Department |
Molecular Biology
|
| Street address |
185 Cambridge Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02114 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21741 |
Illumina HiSeq 4000 (Danio rerio) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE81893 |
Genome-wide maps of histone variant H3.3 occupancy in zebrafish cardiomyocytes |
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| Relations |
| BioProject |
PRJNA323350 |
| SRA |
SRP075715 |
