NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE83834 Query DataSets for GSE83834
Status Public on Aug 21, 2018
Title RHBDF2 in Stromal Fibroblasts Mediates TGF-b Signal and Enhances Cancer Cell Invasion via Intercellular Cross-Talk
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Cancer-associated fibroblasts (CAFs) existing in tumor stroma play a crucial role in tumor progression. Here, we show that stromal fibroblasts near cancer cells are likely to display up-regulated RHBDF2 expression caused by chronic stimulation from pro-inflammatory cytokines. RHBDF2 promotes both the cleavage of type I transforming growth factor (TGF)-b receptor, through tumor necrosis factor α converting enzyme activation, and the motility of CAFs upon stimulation with TGF-b1. High-motility CAFs can consequently assist cancer cell invasion. Furthermore, the expression profiles of these cytokines are significantly associated with poor prognosis in gastric cancer (GC) patients. These findings highlight the underlying mechanism whereby cancer cells take advantage of CAFs to acquire invasiveness.
 
Overall design 11 matched normal and cancer fibroblast cell lines from diffused type gastric cancer and normal samples
 
Contributor(s) Nandi T, Ishimoto T, Tan P
Citation(s) 28390866
Submission date Jun 28, 2016
Last update date May 15, 2019
Contact name Tannistha Nandi
E-mail(s) nandit@gis.a-star.edu.sg
Phone 68088125
Organization name Genome Institute of Singapore
Department Cancer Therapeutics & Stratified Oncology
Street address 60 Biopolis Street, Genome, #02-01
City Singapore
ZIP/Postal code 138672
Country Singapore
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (22)
GSM2219370 NF_33
GSM2219371 NF_37
GSM2219372 NF_38
Relations
BioProject PRJNA327180
SRA SRP077565

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83834_GeneLevelFPKMmatrix.xlsx 8.3 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap