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Status |
Public on Aug 21, 2018 |
Title |
RHBDF2 in Stromal Fibroblasts Mediates TGF-b Signal and Enhances Cancer Cell Invasion via Intercellular Cross-Talk |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Cancer-associated fibroblasts (CAFs) existing in tumor stroma play a crucial role in tumor progression. Here, we show that stromal fibroblasts near cancer cells are likely to display up-regulated RHBDF2 expression caused by chronic stimulation from pro-inflammatory cytokines. RHBDF2 promotes both the cleavage of type I transforming growth factor (TGF)-b receptor, through tumor necrosis factor α converting enzyme activation, and the motility of CAFs upon stimulation with TGF-b1. High-motility CAFs can consequently assist cancer cell invasion. Furthermore, the expression profiles of these cytokines are significantly associated with poor prognosis in gastric cancer (GC) patients. These findings highlight the underlying mechanism whereby cancer cells take advantage of CAFs to acquire invasiveness.
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Overall design |
11 matched normal and cancer fibroblast cell lines from diffused type gastric cancer and normal samples
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Contributor(s) |
Nandi T, Ishimoto T, Tan P |
Citation(s) |
28390866 |
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Submission date |
Jun 28, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Tannistha Nandi |
E-mail(s) |
nandit@gis.a-star.edu.sg
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Phone |
68088125
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Organization name |
Genome Institute of Singapore
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Department |
Cancer Therapeutics & Stratified Oncology
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Street address |
60 Biopolis Street, Genome, #02-01
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City |
Singapore |
ZIP/Postal code |
138672 |
Country |
Singapore |
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Platforms (1) |
GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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Samples (22)
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Relations |
BioProject |
PRJNA327180 |
SRA |
SRP077565 |