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Series GSE84024 Query DataSets for GSE84024
Status Public on Jul 06, 2016
Title Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation in rhesus monkeys
Organism Macaca mulatta
Experiment type Methylation profiling by genome tiling array
Summary This study mapped the genome wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through two years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females.
 
Overall design Altogether 71 T cell DNA samples were used in 4 different groups (male control, male stress, female control, female stress) at 4 different developmental stage (1 month, before weaning at 6-7 months, after weaning at 9-10 months, and after 2 years at 26-30 months) having 3-6 samples per each group. The DNA samples were pooled in each group and then subjected to Whole Genome Amplification in triplicates.
 
Contributor(s) Massart R, Suderman MJ, Suomi SJ, Szyf M
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jul 05, 2016
Last update date Jul 19, 2016
Contact name Moshe Szyf
E-mail(s) moshe.szyf@mcgill.ca
Organization name McGill University
Department Pharmacology
Street address McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 1309
City Montreal
State/province Quebec
ZIP/Postal code H3G 1Y6
Country Canada
 
Platforms (1)
GPL22112 Agilent-037581 rhesus promoter tiling 2011 array (Feature number version)
Samples (48)
GSM2225820 CD3-Tcell_male_2years_control_r1
GSM2225821 CD3-Tcell_male_2years_control_r2
GSM2225822 CD3-Tcell_male_2years_control_r3
This SubSeries is part of SuperSeries:
GSE84028 Ankyrin-3 as a Molecular Marker of Early Life Stress and Vulnerability to Psychiatric Disorders
Relations
BioProject PRJNA327840

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE84024_RAW.tar 2.2 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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