|
| Status |
Public on Jan 10, 2017 |
| Title |
Genomic hallmarks of localized, non-indolent prostate cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences and 277 additional whole-exome sequences from localized, non-indolent prostate tumours with similar clinical risk profiles, and carried out RNA and methylation analyses in a subset. These tumours had a paucity of clinically actionable single nucleotide variants, unlike those seen in metastatic disease. Rather, a significant proportion of tumours harboured recurrent non-coding aberrations, large-scale genomic rearrangements, and alterations in which an inversion repressed transcription within its boundaries. Local hypermutation events were frequent, and correlated with specific genomic profiles. Numerous molecular aberrations were prognostic for disease recurrence, including several DNA methylation events, and a signature comprised of these aberrations outperformed well-described prognostic biomarkers. We suggest that intensified treatment of genomically aggressive localized prostate cancer may improve cure rates.
|
| |
|
| Overall design |
In total we have 73 samples across 3 different batches. Batch 1 and 3 are based on HuGene2.0 platform whereas batch 2 is based on HTA2.0 platform
|
| |
|
| Contributor(s) |
Shiah Y, Boutros PC, Bristow RG, Fraser M |
| Citation(s) |
28068672, 34716314, 34824250 |
| Submission date |
Jul 05, 2016 |
| Last update date |
Dec 15, 2021 |
| Contact name |
Yu-Jia Shiah |
| E-mail(s) |
sylvia.shiah@oicr.on.ca
|
| Organization name |
Ontario Institute for Cancer Research
|
| Department |
Informatics and Bio-computing
|
| Street address |
MaRS Centre 661 University Avenue Suite 510
|
| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5G 0A3 |
| Country |
Canada |
| |
|
| Platforms (2) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
| Samples (73)
|
|
| This SubSeries is part of SuperSeries: |
| GSE84043 |
Genomic hallmarks of localized, non-indolent prostate cancer |
|
| Relations |
| BioProject |
PRJNA327864 |
Less...
More...