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| Status |
Public on Nov 05, 2019 |
| Title |
Zebrafish liver transcriptome in response to chronic treatment with environmentally relevant concentrations of imatinib mesylate |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by array
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| Summary |
Imatinib mesylate (IM) a protein kinase inhibitor drug that selectively inhibits certain oncogenic mutant protein tyrosine kinases. After application, IM is via hospital and municipal waste water effluents released into the aquatic environment, where it can harm non-target organisms. The aim of this study was to evaluate changes in gene transcription in liver of adult F1 zebrafish (Danio rerio) continuously exposed to IM at environmentaly relevant concentrations of 0.01 µg/L and 1 µg/L.
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| Overall design |
One color design, control and treatment in two concentrations; 6 pools of 1-3 individuals per treatment
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| |
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| Contributor(s) |
Baebler Š, Rotter A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 14, 2016 |
| Last update date |
Nov 06, 2019 |
| Contact name |
Spela Baebler |
| E-mail(s) |
spela.baebler@nib.si
|
| Organization name |
National Institute of Biology
|
| Department |
Department of Biotechnology and Systems Biology
|
| Street address |
Vecna pot 111
|
| City |
Ljubljana |
| ZIP/Postal code |
1000 |
| Country |
Slovenia |
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| Platforms (1) |
| GPL14664 |
Agilent-026437 D. rerio (Zebrafish) Oligo Microarray V3 (Probe Name version) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA329075 |
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