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| Status |
Public on Sep 15, 2007 |
| Title |
Identification of IL-1 and IL-6-responsive genes in human monocyte-derived macrophages |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Using whole-genome Affymetrix microarrays (HG-U133A), we characterized the transcriptome profile of cultured human macrophages stimulated for 4 h with interleukin 1 (IL-1) or interleukin 6 (IL-6). We found that, in distinction to liver cells, IL-1 is much more potent than IL-6 in modifying macrophage gene expression, although considerable heterogeneity in response of macrophages deriving from individual blood donors was observed. The obtained results permitted to identify a large number of cytokine-responsive genes. coding for proteins of unknown function that are now being studied in our laboratory. They may represent novel targets in the anti-inflammatory therapy.
Keywords: Cytokine response
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| Overall design |
Analysis of the transcriptome of human monocyte-derived macrophages stimulated in vitro by low doses of IL-1 or IL-6.
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| Contributor(s) |
Koj A, Jura J, Korostynski M, Piechota M |
| Citation(s) |
18498781 |
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| Submission date |
Jul 18, 2007 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Marcin Piechota |
| E-mail(s) |
marpiech@if-pan.krakow.pl
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| Phone |
(+4812) 6623328
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| Organization name |
Institute of Pharmacology PAS
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| Department |
Molecular Neuropharmacology
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| Street address |
Smetna 12
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| City |
Krakow |
| ZIP/Postal code |
31-343 |
| Country |
Poland |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (15)
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| GSM211503 |
Control, Rep4 |
| GSM211504 |
Control, Rep5 |
| GSM211505 |
IL-1, Rep1 |
| GSM211506 |
IL-1, Rep2 |
| GSM211507 |
IL-1, Rep3 |
| GSM211508 |
IL-1, Rep4 |
| GSM211509 |
IL-1, Rep5 |
| GSM211510 |
IL-6, Rep1 |
| GSM211511 |
IL-6, Rep2 |
| GSM211512 |
IL-6, Rep3 |
| GSM211513 |
IL-6, Rep4 |
| GSM211514 |
IL-6, Rep5 |
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| Relations |
| BioProject |
PRJNA101635 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8515_RAW.tar |
31.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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