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| Status |
Public on Dec 31, 2017 |
| Title |
Methylomes of wild-type and MeCP2 knockout brain cells |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
By performing whole genome methylome analysis in MeCP2 knock-out mice brain, we identify both hypo- and hypermethylated regions overlapping with MeCP2 binding sites. Hypermethylation was mainly observed at CpG promoters, suggesting that MeCP2 contributes to the protection of these regions from methylation in brain.
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| Overall design |
Whole genome bisulfite sequencing profiles were generated for wild type and MeCP2 KO cells, 1 replicate each.
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| Contributor(s) |
Meissner A, Jeltsch A |
| Citation missing |
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| Submission date |
Aug 12, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Rahul Karnik |
| E-mail(s) |
rahul@genebrew.com
|
| Organization name |
None
|
| Street address |
419 Broadway
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02138 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA338763 |
| SRA |
SRP081475 |
