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Status |
Public on Jun 30, 2017 |
Title |
Identification of long non coding RNAs associated with self-renewal capacity of rat neural stem cells exposed to sevoflurane |
Organism |
Rattus norvegicus |
Experiment type |
Non-coding RNA profiling by array
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Summary |
To identify the differential porfile of long non coding RNAs in neural stem cells exposed to sevoflurane compared with control gas(21% oxygen,5%CO2,),We employed the rat long non-coding RNA array as a discovery platform to identify genes with potential to regulate self-renewal capacity of rat neural stem cells exposed to sevoflurane.
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Overall design |
Sevoflurane exposure induced gene expression in cultrued neural stem cells derived from hippocampus was detected at 6 hours after exposure to 2.4%sevoflurane or control gas.Two different independent experiments were performed at 6 hours using tow samples of cultrued neural stem cells with exposure to sevoflurane or control gas.
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Contributor(s) |
Lu G, Xu S |
Citation(s) |
- Lu G, Xu H, Zhao W, Zhang J et al. Upregulation of long noncoding RNA Gadd45a is associated with sevoflurane-induced neurotoxicity in rat neural stem cells. Neuroreport 2018 May 23;29(8):605-614. PMID: 29521679
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Submission date |
Aug 20, 2016 |
Last update date |
Jun 14, 2018 |
Contact name |
Guo-lin Lu |
E-mail(s) |
Drguolinlu@hotmail.com
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Organization name |
maternity and children Hospital of Fujian Province
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Department |
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Lab |
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Street address |
No18 Daoshan Road Gulou District
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City |
Fuzhou |
State/province |
Fujian |
ZIP/Postal code |
350001 |
Country |
China |
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Platforms (1) |
GPL15690 |
Arraystar Rat LncRNA microarray (026403) |
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Samples (2) |
GSM2286400 |
hippocampal neural stem cells_6hr_2.4%sevoflurane_rep1 |
GSM2286401 |
hippocampal neural stem cells_6hr_0%sevoflurane_rep1 |
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Relations |
BioProject |
PRJNA339614 |