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Series GSE86091 Query DataSets for GSE86091
Status Public on Aug 22, 2017
Title cis-regulatory landscape in ccRCC [tissue]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary VHL loss is the most common genetic alteration event in ccRCC, but its effect on epigenetic landscape has not been elucidated previously. By performing histone modifications (H3K27ac, H3K4me1, H3K4me3) from ccRCC cell lines, we describe the genome-wide cis-regulatory landscapes of VHL-deficient ccRCC tumors. We show that ccRCCs exhibit a pervasive gain of enhancers around hypoxic and metabolic transcriptional targets.
 
Overall design Histone ChIP-Seq in primary normal-tumor tissue pairs of ccRCC
 
Contributor(s) Yao X, Tan P
Citation(s) 28893800
Submission date Aug 26, 2016
Last update date May 15, 2019
Contact name Xiaosai Yao
E-mail(s) xiaosai.yao@gmail.com, yao.xiaosai@gene.com
Phone +65 68088271
Organization name Genome Institute of Singapore
Street address 60 Biopolis Street, Genome, #02-01
City Singapore
ZIP/Postal code 138672
Country Singapore
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (72)
GSM2293404 20431713N Input
GSM2293405 20431713N H3K27ac ChIP-seq
GSM2293406 20431713N H3K4me1 ChIP-seq
This SubSeries is part of SuperSeries:
GSE86095 VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma
Relations
BioProject PRJNA340239
SRA SRP083008

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE86091_RAW.tar 30.5 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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