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| Status |
Public on Aug 31, 2018 |
| Title |
Transcriptome characterization of triple negative breast cancer [Italy] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Triple negative breast cancer (TNBC) represents a challenging tumor type due to their poor prognosis and limited treatment options. It is well recognize that clinical and molecular heterogeneity of TNBC is driven in part by mRNA and lncRNAs. To stratify TNBCs, we profiled mRNAs and lncRNA in 158 adjuvant TNBC tumors using an Affymetrix microarray platform. Lehmann clustering analysis allowed us to identify TNBC subtypes featuring unique lncRNA expression patterns, disease free and overall survival rates and particular gene ontology enrichments (performed with GSEA algorithm).
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| Overall design |
Breast cancer tumors were collected from the archives of the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan (INT) after a carefully histopathological review by two training pathologist, according to the following criteria: adjuvant therapy and collection of the surgical sample without any treatment. We obtain triple negative tumors (ER-, PR- and Her2-) and tumors from other immunophenotype (ER+, PR+ or/and Her2+) by microdissection of tumoral cells for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Betlran-Anaya FO, Romero-Cordoba SL, Rodriguez-Cuevas S, Bautista-Pina V, Maffuz-Aziz A, Baroni S, Iorio M, Hidalgo-Miranda A |
| Citation(s) |
30115973, 31261762, 30705400, 33854067 |
| Submission date |
Sep 14, 2016 |
| Last update date |
May 06, 2021 |
| Contact name |
Sandra Lorena Romero-Cordoba |
| E-mail(s) |
sromero_cordoba@hotmail.com
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| Organization name |
National Instute of Genomic Medicine
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| Department |
Cancer Genomics
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| Street address |
Periférico Sur No. 4809, Col. Arenal Tepepan, Delegación Tlalpan. México, D.F.
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| City |
Mexico |
| State/province |
Mexico |
| ZIP/Postal code |
14610 |
| Country |
Mexico |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (100)
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| This SubSeries is part of SuperSeries: |
| GSE86948 |
A microRNA signature identifies four subtypes of triple-negative breast cancer and correlates miR-342-3p as a regulator of the lactate metabolic pathway through silencing the monocarboxylate transporter 1 |
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| Relations |
| BioProject |
PRJNA343045 |
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