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| Status |
Public on Sep 20, 2017 |
| Title |
Conserved and species specific molecular denominators in mammalian aging [rat] |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Aging is a complex phenomenon involving functional decline in multiple physiological systems. We focused on skeletal muscle to identify pathways that modulate function and healthspan by global expression profiles and specific mechanisms fundamental to aging processes. Our experimental design integrated comparative analysis of mice, rats, rhesus monkeys and humans and targeted three key time points during their lifespans. Pathways related to oxidative stress, inflammation and nutrient signaling, which function collectively to affect the quality and status of mitochondria, emerged across all species with age. Notably, mitochondrial transcript levels were better preserved in aging human muscle, suggesting an evolution-driven fitness more robust than in other species. The identification of these conserved pathways uncovers common molecular mechanisms intrinsic to health and lifespan, while unveiling of species-specific pathways emphasizes the importance of human studies for devising optimal therapeutic modalities to slow the aging process.
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| Overall design |
RNA extracted from skeletal muscle biopsies of five young, five middle-aged, and five old male Fisher-344 rats was analyzed by gene expression microarray analysis.
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| Contributor(s) |
Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R |
| Citation(s) |
28649426 |
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| Submission date |
Sep 19, 2016 |
| Last update date |
Jun 22, 2020 |
| Contact name |
Supriyo De |
| Organization name |
NIA-IRP, NIH
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| Department |
Laboratory of Genetics and Genomics
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| Lab |
Computational Biology & Genomics Core
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| Street address |
251 Bayview Blvd
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| City |
Baltimore |
| State/province |
Maryland |
| ZIP/Postal code |
21224 |
| Country |
USA |
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| Platforms (1) |
| GPL6101 |
Illumina ratRef-12 v1.0 expression beadchip |
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| Samples (15)
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| GSM2322485 |
Vastus lateralis muscle_Young_replicate_1_rat |
| GSM2322486 |
Vastus lateralis muscle_Young_replicate_2_rat |
| GSM2322487 |
Vastus lateralis muscle_Young_replicate_3_rat |
| GSM2322488 |
Vastus lateralis muscle_Young_replicate_4_rat |
| GSM2322489 |
Vastus lateralis muscle_Young_replicate_5_rat |
| GSM2322490 |
Vastus lateralis muscle_Middle-aged_replicate_1_rat |
| GSM2322491 |
Vastus lateralis muscle_Middle-aged_replicate_2_rat |
| GSM2322492 |
Vastus lateralis muscle_Middle-aged_replicate_3_rat |
| GSM2322493 |
Vastus lateralis muscle_Middle-aged_replicate_4_rat |
| GSM2322494 |
Vastus lateralis muscle_Middle-aged_replicate_5_rat |
| GSM2322495 |
Vastus lateralis muscle_Old_replicate_1_rat |
| GSM2322496 |
Vastus lateralis muscle_Old_replicate_2_rat |
| GSM2322497 |
Vastus lateralis muscle_Old_replicate_3_rat |
| GSM2322498 |
Vastus lateralis muscle_Old_replicate_4_rat |
| GSM2322499 |
Vastus lateralis muscle_Old_replicate_5_rat |
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| This SubSeries is part of SuperSeries: |
| GSE87109 |
Conserved and species-specific molecular denominators in mammalian skeletal muscle aging |
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| Relations |
| BioProject |
PRJNA343555 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE87107_Non-normalized_data.txt.gz |
1.1 Mb |
(ftp)(http) |
TXT |
| GSE87107_RAW.tar |
2.8 Mb |
(http)(custom) |
TAR |
| Processed data included within Sample table |
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